Predicting essential proteins from protein-protein interactions using order statistics.
J Theor Biol
; 480: 274-283, 2019 11 07.
Article
in En
| MEDLINE
| ID: mdl-31251944
ABSTRACT
Many computational methods have been proposed to predict essential proteins from protein-protein interaction (PPI) networks. However, it is still challenging to improve the prediction accuracy. In this study, we propose a new method, esPOS (essential proteins Predictor using Order Statistics) to predict essential proteins from PPI networks. Firstly, we refine the networks by using gene expression information and subcellular localization information. Secondly, we design some new features, which combine the protein predicted secondary structure with PPI network. We show that these new features are useful to predict essential proteins. Thirdly, we optimize these features by using a greedy method, and combine the optimized features by order statistic method. Our method achieves the prediction accuracy of 0.76-0.79 on two network datasets. The proposed method is available at https//sourceforge.net/projects/espos/.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Algorithms
/
Statistics as Topic
/
Computational Biology
/
Protein Interaction Maps
Type of study:
Prognostic_studies
/
Risk_factors_studies
Language:
En
Year:
2019
Type:
Article