Inhibiting or Accelerating Crystallization of Pharmaceuticals by Manipulating Polymer Solubility.
Mol Pharm
; 16(8): 3720-3725, 2019 08 05.
Article
in En
| MEDLINE
| ID: mdl-31268333
ABSTRACT
Polymers play a central role in controlling the crystallization of pharmaceuticals with effects as divergent as amorphous form stabilization and the acceleration of crystallization. Here, using pyrazinamide and hydrochlorothiazide as model pharmaceuticals, it is demonstrated that the same functional group interactions are responsible for these opposing behaviors and that whether a polymer speeds or slows a crystallization can be controlled by polymer solubility. This concept is applied for the discovery of polymers to maintain drug supersaturation in solution the strength of functional group interactions between drug and polymer is assessed through polymer-induced heteronucleation, and soluble polymers containing the strongest-interacting functional groups with drug are shown to succeed as precipitation inhibitors.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Polymers
/
Drug Carriers
/
Chemistry, Pharmaceutical
Language:
En
Year:
2019
Type:
Article