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KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors - TORC1/2 Inhibition as Salvage Strategy.
Mühlenberg, Thomas; Ketzer, Julia; Heinrich, Michael C; Grunewald, Susanne; Marino-Enriquez, Adrian; Trautmann, Marcel; Hartmann, Wolfgang; Wardelmann, Eva; Treckmann, Jürgen; Worm, Karl; Bertram, Stefanie; Herold, Thomas; Schildhaus, Hans-Ulrich; Glimm, Hanno; Stenzinger, Albrecht; Brors, Benedikt; Horak, Peter; Hohenberger, Peter; Fröhling, Stefan; Fletcher, Jonathan A; Bauer, Sebastian.
Affiliation
  • Mühlenberg T; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany. thomas.muehlenberg@uk-essen.de Sebastian.bauer@uk-essen.de.
  • Ketzer J; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Heinrich MC; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.
  • Grunewald S; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Marino-Enriquez A; Portland VA Health Care System, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
  • Trautmann M; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.
  • Hartmann W; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Wardelmann E; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Treckmann J; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.
  • Worm K; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.
  • Bertram S; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.
  • Herold T; Department of Visceral and Transplant Surgery, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.
  • Schildhaus HU; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Germany.
  • Glimm H; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Germany.
  • Stenzinger A; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Brors B; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Germany.
  • Horak P; Institute of Pathology, Universitätsmedizin Göttingen, Göttingen, Germany.
  • Hohenberger P; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Fröhling S; Department of Translational Oncology, National Center for Tumor Diseases (NCT) Dresden, Dresden University Hospital, Dresden, Germany.
  • Fletcher JA; German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Bauer S; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Mol Cancer Ther ; 18(11): 1985-1996, 2019 11.
Article in En | MEDLINE | ID: mdl-31308077
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Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Proto-Oncogene Proteins c-kit / Drug Resistance, Neoplasm / Gastrointestinal Stromal Tumors / Protein Kinase Inhibitors / High-Throughput Nucleotide Sequencing / Mutation Limits: Female / Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Proto-Oncogene Proteins c-kit / Drug Resistance, Neoplasm / Gastrointestinal Stromal Tumors / Protein Kinase Inhibitors / High-Throughput Nucleotide Sequencing / Mutation Limits: Female / Humans Language: En Year: 2019 Type: Article