Evaluation of Serum Glucagon-Like Peptide 1 and Vitamin D Levels in Elderly Patients with Bone Fractures.
Med Princ Pract
; 29(3): 219-224, 2020.
Article
in En
| MEDLINE
| ID: mdl-31311025
ABSTRACT
OBJECTIVES:
To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures. MATERIALS ANDMETHODS:
This study included 56 patients and 31 control subjects. The patients included were those aged ≥65 years who were admitted to our hospital with a diagnosis of bone fracture. The control group comprised age-matched, healthy individuals. Levels of serum vitamin D and GLP-1 were measured and compared between the 2 groups.RESULTS:
Significant differences were noted between the groups in terms of serum levels of vitamin D (p < 0.001) and serum levels of GLP-1 (p < 0.001). A positive correlation was observed between serum levels of vitamin D and GLP-1.CONCLUSION:
Serum levels of GLP-1 were found to be significantly lower in elderly patients with bone fracture compared to healthy adults. In addition, a significant correlation was found between decreased vitamin D and GLP-1 levels. These results may therefore demonstrate the protective effects of GLP-1 on bone structure and metabolism, similar to those of vitamin D.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Vitamin D
/
Fractures, Bone
/
Glucagon-Like Peptide 1
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Year:
2020
Type:
Article