Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction.
EBioMedicine
; 46: 264-273, 2019 Aug.
Article
in En
| MEDLINE
| ID: mdl-31345784
ABSTRACT
BACKGROUND:
Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators also provide novel therapeutic opportunities for treating inflammatory disease. However, the regulation of these molecules following acute myocardial infarction (MI) remains of interest.METHODS:
In this prospective observational study we aimed to profile plasma levels of SPMs in ST-elevation MI (STEMI) patients during the first week following MI. Plasma LM concentrations were measured in patients with STEMI (nâ¯=â¯15) at three time points and compared with stable coronary artery disease (CAD; nâ¯=â¯10) and healthy controls (nâ¯=â¯10).FINDINGS:
Our main findings were (i) Immediately after onset of MI and before peak troponin T levels, STEMI patients had markedly increased levels of SPMs as compared with healthy controls and stable CAD patients, with levels of these mediators declining during follow-up. (ii) The increase in SPMs primarily reflected an increase in docosapentaenoic acid- and docosahexaenoic acid-derived protectins. (iii) Several individual protectins were correlated with the rapid increase in neutrophil counts, but not with CRP. (iv) A shift in 5-LOX activity from the leukotriene B4 pathway to the pro-resolving RvTs was observed.INTERPRETATION:
The temporal regulation of SPMs indicates that resolution mechanisms are activated early during STEMI as part of an endogenous mechanism to initiate repair. Thus strategies to boost the activity and/or efficacy of these endogenous mechanisms may represent novel therapeutic opportunities for treatment of patients with MI. FUND This work was supported by grants from the South-Eastern Norwegian regional health authority, the European Research Council under the European Union's Horizon 2020 research and innovation program, a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society, and the Barts Charity.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Inflammation Mediators
/
ST Elevation Myocardial Infarction
/
Lipids
Type of study:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2019
Type:
Article