Human Artificial Chromosomes that Bypass Centromeric DNA.

Logsdon, Glennis A; Gambogi, Craig W; Liskovykh, Mikhail A; Barrey, Evelyne J; Larionov, Vladimir; Miga, Karen H; Heun, Patrick; Black, Ben E

Logsdon, Glennis A; Gambogi, Craig W; Liskovykh, Mikhail A; Barrey, Evelyne J; Larionov, Vladimir; Miga, Karen H; Heun, Patrick; Black, Ben E.

Affiliation

Logsdon GA; Department of Biochemistry and Biophysics, Graduate Program in Biochemistry and Molecular Biophysics, and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gambogi CW; Department of Biochemistry and Biophysics, Graduate Program in Biochemistry and Molecular Biophysics, and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Liskovykh MA; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Barrey EJ; Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
Larionov V; Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Miga KH; Center for Biomolecular Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Heun P; Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
Black BE; Department of Biochemistry and Biophysics, Graduate Program in Biochemistry and Molecular Biophysics, and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: blackbe@pennmedicine.upenn.edu.

Cell ; 178(3): 624-639.e19, 2019 07 25.

Article in En | MEDLINE | ID: mdl-31348889

Subject(s)

Centromere/metabolism; Chromosomes, Artificial, Human/metabolism; DNA, Satellite/metabolism; Binding Sites; Cell Line, Tumor; Centromere/genetics; Centromere Protein A/genetics; Centromere Protein A/metabolism; Centromere Protein B/deficiency; Centromere Protein B/genetics; Centromere Protein B/metabolism; Epigenesis, Genetic; Humans; Nucleosomes/chemistry; Nucleosomes/metabolism; Plasmids/genetics; Plasmids/metabolism

Key words

HAC; centromere; chromatin; epigenetics; histone; human artificial chromosome; kinetochore; mitosis; nucleosome; synthetic chromosome

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Full text: 1 Database: MEDLINE Main subject: DNA, Satellite / Centromere / Chromosomes, Artificial, Human Limits: Humans Language: En Year: 2019 Type: Article

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Full text: 1 Database: MEDLINE Main subject: DNA, Satellite / Centromere / Chromosomes, Artificial, Human Limits: Humans Language: En Year: 2019 Type: Article