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Gd-encapsulated carbonaceous dots for accurate characterization of tumor vessel permeability in magnetic resonance imaging.
Wu, Yongyi; Yan, Yuling; Gao, Xuan; Yang, Lili; Li, Ying; Guo, Xiaolu; Xie, Jin; Wang, Kai; Sun, Xilin.
Affiliation
  • Wu Y; Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Yan Y; Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Gao X; Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Yang L; Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Li Y; Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Guo X; Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Xie J; Department of Chemistry and Bio-Imaging Research Center, The University of Georgia Athens, GA, USA. Electronic address: jinxie@uga.edu.
  • Wang K; Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China. Electronic address: wangkai@hrbmu.edu.cn.
  • Sun X; Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China. Electronic address: sunxl@ems.hrbmu.edu.cn.
Nanomedicine ; 21: 102074, 2019 10.
Article in En | MEDLINE | ID: mdl-31376571
ABSTRACT
The assessment of vascular permeability of malignant tumor plays an important role in the diagnosis and treatment of cancer. Dynamic contrast-enhanced magnetic resonance image (DCE-MRI) using Gd-encapsulated carbonaceous dots and Gd-DTPA-BMA as contrast agents was performed in 4T1 mouse breast cancer and HCC827 human non-small-cell lung cancer (NSNLC) xenograft models. Histopathological parameters of tumor vascularity microvessel density (MVD), microvessel area (MVA), endothelial area (EA) and α-SMA CD31 Co-expression (α-SMA/CD31%) were compared with the DCE-MRI parameters. Results demonstrated that DCE-MRI with the new nanoparticle Gd@C-dots can noninvasively evaluate vascular permeability. Ktrans measured by DCE-MRI with Gd@C-dots is an accurate parameter for the characterization of tumor permeability. EA is a reliable microvessel parameter to evaluate vessel permeability.
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Full text: 1 Database: MEDLINE Main subject: Capillary Permeability / Endothelium, Vascular / Magnetic Resonance Imaging / Mammary Neoplasms, Animal / Carcinoma, Non-Small-Cell Lung / Contrast Media / Nanoparticles / Gadolinium / Lung Neoplasms / Neovascularization, Pathologic Limits: Animals / Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Capillary Permeability / Endothelium, Vascular / Magnetic Resonance Imaging / Mammary Neoplasms, Animal / Carcinoma, Non-Small-Cell Lung / Contrast Media / Nanoparticles / Gadolinium / Lung Neoplasms / Neovascularization, Pathologic Limits: Animals / Humans Language: En Year: 2019 Type: Article