The global motion affecting electron transfer in Plasmodium falciparum type II NADH dehydrogenases: a novel non-competitive mechanism for quinoline ketone derivative inhibitors.

Xie, Tao; Wu, Zhixiang; Gu, Jinke; Guo, Runyu; Yan, Xiao; Duan, Huaichuan; Liu, Xinyu; Liu, Wei; Liang, Li; Wan, Hua; Luo, Yafei; Tang, Dianyong; Shi, Hubing; Hu, Jianping

Xie, Tao; Wu, Zhixiang; Gu, Jinke; Guo, Runyu; Yan, Xiao; Duan, Huaichuan; Liu, Xinyu; Liu, Wei; Liang, Li; Wan, Hua; Luo, Yafei; Tang, Dianyong; Shi, Hubing; Hu, Jianping.

Affiliation

Xie T; College of Pharmacy and Biological Engineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Chengdu University, Chengdu, 610106, China. hjpcdu@163.com.

Phys Chem Chem Phys ; 21(33): 18105-18118, 2019 Aug 21.

Article in En | MEDLINE | ID: mdl-31396604

Subject(s)

Antimalarials/chemistry; Ketones/chemistry; NADH Dehydrogenase/antagonists & inhibitors; Plasmodium falciparum/enzymology; Protozoan Proteins/antagonists & inhibitors; Protozoan Proteins/chemistry; Quinolines/chemistry; Electron Transport; Flavin-Adenine Dinucleotide/chemistry; Hydrogen Bonding; Models, Molecular; Molecular Structure; NAD/chemistry; NADH Dehydrogenase/chemistry; Oxidation-Reduction; Protein Binding; Structure-Activity Relationship; Thermodynamics

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Full text: 1 Database: MEDLINE Main subject: Plasmodium falciparum / Quinolines / Protozoan Proteins / Ketones / NADH Dehydrogenase / Antimalarials Type of study: Guideline / Prognostic_studies Language: En Year: 2019 Type: Article

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