A prospective randomized study of efficacy of 2 treatment protocols in preventing recurrence of clinical signs in 51 male cats with obstructive idiopathic cystitis.
J Vet Intern Med
; 33(5): 2117-2123, 2019 Sep.
Article
in En
| MEDLINE
| ID: mdl-31400046
ABSTRACT
BACKGROUND:
Urethral obstruction (UO) is a common complication of feline idiopathic cystitis (FIC). Robust treatment recommendations to prevent its recurrence are scarce.OBJECTIVES:
To evaluate meloxicam treatment for prevention of clinical recrudescence in male cats with obstructive FIC. ANIMALS Fifty-one client-owned cats.METHODS:
Prospective, randomized clinical trial. Every male cat with FIC-associated UO was deemed eligible for the study and was recruited during hospitalization. After discharge, cats were treated with phenoxybenzamine and alprazolam for 2 weeks, with (24 cats) or without (27 cats) low-dose meloxicam (0.025 mg/kg/day PO) and monitored for 6 months.RESULTS:
Cumulative number (%) of cats with recurrent UO at 10 days, 1-, 2-, and 6-months after discharge was 1 (2%), 2 (4%), 4 (8%), and 8 (16%), respectively. Overall, 12 (24%) cats experienced signs of recurrent FIC within 6 months, with (8 cats) or without (4 cats) concurrent UO. No difference in the cumulative incidence of UO within 6 months was detected with addition of meloxicam (odds ratio [95% confidence interval], 0.63 [0.13-2.97]; P = .70). All cats were alive at 6 months. CONCLUSIONS AND CLINICAL IMPORTANCE No clinical benefit was detected with the addition of low-dose meloxicam to phenoxybenzamine and alprazolam treatment for 2 weeks after discharge. Nevertheless, this study was underpowered to identify potential differences, and its findings must be corroborated in larger studies.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Urethral Obstruction
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Cat Diseases
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Anti-Inflammatory Agents, Non-Steroidal
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Cystitis
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Meloxicam
Type of study:
Diagnostic_studies
/
Guideline
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Year:
2019
Type:
Article