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Design, synthesis and evaluation of phthalazinone thiohydantoin-based derivative as potent PARP-1 inhibitors.
Zhong, Yi; Meng, Ying; Xu, Xi; Zhao, Lulu; Li, Zhiyu; You, Qidong; Bian, Jinlei.
Affiliation
  • Zhong Y; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
  • Meng Y; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
  • Xu X; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
  • Zhao L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
  • Li Z; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
  • You Q; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
  • Bian J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Bioorg Chem ; 91: 103181, 2019 10.
Article in En | MEDLINE | ID: mdl-31404795
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Full text: 1 Database: MEDLINE Main subject: Phthalazines / Thiohydantoins / Breast Neoplasms / Drug Design / Poly(ADP-ribose) Polymerase Inhibitors / Poly (ADP-Ribose) Polymerase-1 / Imidazoles Type of study: Evaluation_studies Limits: Female / Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Phthalazines / Thiohydantoins / Breast Neoplasms / Drug Design / Poly(ADP-ribose) Polymerase Inhibitors / Poly (ADP-Ribose) Polymerase-1 / Imidazoles Type of study: Evaluation_studies Limits: Female / Humans Language: En Year: 2019 Type: Article