In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?

McNicholas, Kym; MacGregor, Melanie N; Gleadle, Jonathan M

McNicholas, Kym; MacGregor, Melanie N; Gleadle, Jonathan M.

Affiliation

McNicholas K; Department of Renal Medicine, Flinders Medical Centre, Flinders University, Bedford Park, SA, 5042, Australia. kym.mcnicholas@flinders.edu.au.
MacGregor MN; College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia. kym.mcnicholas@flinders.edu.au.
Gleadle JM; Future Industries Institute, School of Engineering, University of South Australia, Adelaide, SA, 5095, Australia.

Br J Cancer ; 121(8): 631-639, 2019 10.

Article in En | MEDLINE | ID: mdl-31406300

Subject(s)

Aminolevulinic Acid; Glucose/metabolism; Heme/biosynthesis; Neoplasms/metabolism; Protoporphyrins/metabolism; Tumor Hypoxia; Amino Acid Transport Systems/metabolism; Brain Neoplasms/diagnostic imaging; Brain Neoplasms/drug therapy; Brain Neoplasms/metabolism; Coproporphyrinogens/metabolism; Ferrochelatase/metabolism; Fluorescence; Humans; Iron/metabolism; MicroRNAs/metabolism; Mitochondria/metabolism; Mutation; NADP/metabolism; Neoplasms/diagnostic imaging; Neoplasms/drug therapy; Oncogenes/genetics; Optical Imaging; Peptide Transporter 1/metabolism; Photochemotherapy; Skin Neoplasms/diagnostic imaging; Skin Neoplasms/drug therapy; Skin Neoplasms/metabolism; Symporters/metabolism; Tumor Microenvironment; Urinary Bladder Neoplasms/diagnostic imaging; Urinary Bladder Neoplasms/drug therapy; Urinary Bladder Neoplasms/metabolism

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Full text: 1 Database: MEDLINE Main subject: Protoporphyrins / Tumor Hypoxia / Glucose / Aminolevulinic Acid / Heme / Neoplasms Limits: Humans Language: En Year: 2019 Type: Article

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