Survival benefit of neoadjuvant therapy in patients with non-metastatic pancreatic ductal adenocarcinoma: A propensity matching and intention-to-treat analysis.

Sugimoto, Motokazu; Takahashi, Naoki; Farnell, Michael B; Smyrk, Thomas C; Truty, Mark J; Nagorney, David M; Smoot, Rory L; Chari, Suresh T; Carter, Rickey E; Kendrick, Michael L

Sugimoto, Motokazu; Takahashi, Naoki; Farnell, Michael B; Smyrk, Thomas C; Truty, Mark J; Nagorney, David M; Smoot, Rory L; Chari, Suresh T; Carter, Rickey E; Kendrick, Michael L.

Affiliation

Sugimoto M; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.
Takahashi N; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Farnell MB; Division of Radiology, Mayo Clinic, Rochester, Minnesota.
Smyrk TC; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.
Truty MJ; Division of Pathology, Mayo Clinic, Rochester, Minnesota.
Nagorney DM; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.
Smoot RL; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.
Chari ST; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.
Carter RE; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Kendrick ML; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.

J Surg Oncol ; 120(6): 976-984, 2019 Nov.

Article in En | MEDLINE | ID: mdl-31452208

Subject(s)

Adenocarcinoma/mortality; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Carcinoma, Pancreatic Ductal/mortality; Intention to Treat Analysis; Neoadjuvant Therapy/mortality; Pancreatectomy/mortality; Pancreatic Neoplasms/mortality; Adenocarcinoma/drug therapy; Adenocarcinoma/pathology; Adenocarcinoma/surgery; Adult; Aged; Aged, 80 and over; Carcinoma, Pancreatic Ductal/drug therapy; Carcinoma, Pancreatic Ductal/pathology; Carcinoma, Pancreatic Ductal/surgery; Chemotherapy, Adjuvant; Cohort Studies; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pancreatic Neoplasms/drug therapy; Pancreatic Neoplasms/pathology; Pancreatic Neoplasms/surgery; Prognosis; Propensity Score; Survival Rate; Young Adult; Pancreatic Neoplasms

Key words

neoadjuvant therapy; overall survival; pancreatic cancer; surgical resection; upfront surgery

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Full text: 1 Database: MEDLINE Main subject: Pancreatectomy / Pancreatic Neoplasms / Adenocarcinoma / Antineoplastic Combined Chemotherapy Protocols / Neoadjuvant Therapy / Carcinoma, Pancreatic Ductal / Intention to Treat Analysis Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2019 Type: Article

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