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Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
Kim, Ho Shin; Hammill, Jared T; Scott, Daniel C; Chen, Yizhe; Min, Jaeki; Rector, Jonah; Singh, Bhuvanesh; Schulman, Brenda A; Guy, R Kiplin.
Affiliation
  • Kim HS; Department of Pharmaceutical Sciences , University of Kentucky , Lexington , Kentucky 40508 , United States.
  • Hammill JT; Department of Pharmaceutical Sciences , University of Kentucky , Lexington , Kentucky 40508 , United States.
  • Scott DC; Department of Structural Biology , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 , United States.
  • Chen Y; Department of Pharmaceutical Sciences , University of Kentucky , Lexington , Kentucky 40508 , United States.
  • Min J; Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 , United States.
  • Rector J; Department of Pharmaceutical Sciences , University of Kentucky , Lexington , Kentucky 40508 , United States.
  • Singh B; Department of Surgery, Laboratory of Epithelial Cancer Biology , Memorial Sloan Kettering Cancer Center , New York New York 10065 , United States.
  • Schulman BA; Department of Structural Biology , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 , United States.
  • Guy RK; Department of Molecular Machines and Signaling , Max Planck Institute of Biochemistry , Martinsried 82152 , Germany.
J Med Chem ; 62(18): 8429-8442, 2019 09 26.
Article in En | MEDLINE | ID: mdl-31465221
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Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Pyridones / Cullin Proteins / Intracellular Signaling Peptides and Proteins / NEDD8 Protein Limits: Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Pyridones / Cullin Proteins / Intracellular Signaling Peptides and Proteins / NEDD8 Protein Limits: Humans Language: En Year: 2019 Type: Article