Lifetime of Parahydrogen in Aqueous Solutions and Human Blood.
Chemphyschem
; 20(19): 2408-2412, 2019 10 02.
Article
in En
| MEDLINE
| ID: mdl-31479580
ABSTRACT
Molecular hydrogen has unique nuclear spin properties. Its nuclear spin isomer, parahydrogen (pH2 ), was instrumental in the early days of quantum mechanics and allows to boost the NMR signal by several orders of magnitude. pH2- induced polarization (PHIP) is based on the survival of pH2 spin order in solution, yet its lifetime has not been investigated in aqueous or biological media required for inâ
vivo applications. Herein, we report longitudinal relaxation times (T1 ) and lifetimes of pH2 ( τPOC ) in methanol and water, with or without O2 , NaCl, rhodium-catalyst or human blood. Furthermore, we present a relaxation model that uses T1 and τPOC for more precise theoretical predictions of the H2 spin state in PHIP experiments. All measured T1 values were in the range of 1.4-2â
s and τPOC values were of the order of 10-300 minutes. These relatively long lifetimes hold great promise for emerging inâ
vivo implementations and applications of PHIP.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Hydrogen
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Year:
2019
Type:
Article