Xanthones from the stems of Cudrania tricuspidata and their inhibitory effects on pancreatic lipase and fat accumulation.
Bioorg Chem
; 92: 103234, 2019 11.
Article
in En
| MEDLINE
| ID: mdl-31479985
ABSTRACT
Nine new xanthones, cudracuspixanthones I - Q (12-14, 25, 32-36), and 30 known xanthones (1-11, 15-24, 26-31, 37-39) were isolated from the stems of Cudrania tricuspidata (Moraceae). The structures of isolated compounds were established by using 1D and 2D NMR in combination with HR-TOF-MS. Xanthones from the stems of C. tricuspidata exerted pancreatic lipase inhibitory activity. In addition, cudracuspixanthone P (35), a new xanthone, reduced the fat accumulation in liver cells stimulated with fatty acids. Therefore, these compounds might be beneficial in the treatment of metabolic diseases.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pancreas
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Plant Stems
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Moraceae
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Xanthones
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Lipid Metabolism
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Lipase
Limits:
Humans
Language:
En
Year:
2019
Type:
Article