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Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement.
Radwan, Mohamed O; Ciftci, Halil I; Ali, Taha F S; Ellakwa, Doha E; Koga, Ryoko; Tateishi, Hiroshi; Nakata, Akiko; Ito, Akihiro; Yoshida, Minoru; Okamoto, Yoshinari; Fujita, Mikako; Otsuka, Masami.
Affiliation
  • Radwan MO; Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-Ku, Kumamoto 8620976, Japan.
  • Ciftci HI; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
  • Ali TFS; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt.
  • Ellakwa DE; Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-Ku, Kumamoto 8620976, Japan.
  • Koga R; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
  • Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
  • Nakata A; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
  • Ito A; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
  • Yoshida M; Department of Biochemistry Science, Faculty of Pharmacy, Al-Azhar University (Girls), Nasr City, Cairo 11651, Egypt.
  • Okamoto Y; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
  • Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
  • Otsuka M; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 3510198, Japan.
Molecules ; 24(18)2019 Sep 10.
Article in En | MEDLINE | ID: mdl-31510043
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Full text: 1 Database: MEDLINE Main subject: Trityl Compounds / Sirtuin 2 / Neoplasms Limits: Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Trityl Compounds / Sirtuin 2 / Neoplasms Limits: Humans Language: En Year: 2019 Type: Article