Real-Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co-Encapsulated Ingestion Sensor in HIV-Infected Patients: A Pilot Study.
Clin Transl Sci
; 13(1): 189-194, 2020 01.
Article
in En
| MEDLINE
| ID: mdl-31536156
ABSTRACT
Adherence with antiretroviral therapy is important for preventing disease progression and HIV transmission. The co-encapsulated pill sensor system sends a signal through a cutaneous patch and allows real-time monitoring of pill ingestion. A 16-week pilot study used a sensor system in 15 HIV-infected individuals with real-time monitoring of pill-taking with a personalized short message system text. System acceptability was assessed by survey at weeks 4, 8, 12, and 16. Follow-up occurred in 80% of subjects through 8 weeks. The system effectively collected measures of pill ingestion, which triggered text message reminders. Only 2 of 14 participants stated that co-encapsulated pills were "unable to take" or "poorly tolerated." At least 75% of respondents stated at each visit that the patch was very or somewhat comfortable. With regard to text message reminders, only 10-15% of the participants at any visit did not find the messages to be helpful. Larger studies will define the utility of this system to assess antiretroviral adherence relative to standard measures.
Full text:
1
Database:
MEDLINE
Main subject:
HIV Infections
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Monitoring, Ambulatory
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Anti-HIV Agents
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Drug Compounding
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Medication Adherence
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Year:
2020
Type:
Article