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Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC.
Wei, Lai; Lee, Derek; Law, Cheuk-Ting; Zhang, Misty Shuo; Shen, Jialing; Chin, Don Wai-Ching; Zhang, Allen; Tsang, Felice Ho-Ching; Wong, Ceci Lok-Sze; Ng, Irene Oi-Lin; Wong, Carmen Chak-Lui; Wong, Chun-Ming.
Affiliation
  • Wei L; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Lee D; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Law CT; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Zhang MS; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Shen J; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Chin DW; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Zhang A; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Tsang FH; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Wong CL; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Ng IO; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Wong CC; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Wong CM; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Nat Commun ; 10(1): 4681, 2019 10 15.
Article in En | MEDLINE | ID: mdl-31615983
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Drug Resistance, Neoplasm / Phosphoglycerate Dehydrogenase / Sorafenib / Liver Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Drug Resistance, Neoplasm / Phosphoglycerate Dehydrogenase / Sorafenib / Liver Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Year: 2019 Type: Article