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Therapeutic Targeting of the Colorectal Tumor Stroma.
Fridman, Wolf H; Miller, Ian; Sautès-Fridman, Catherine; Byrne, Annette T.
Affiliation
  • Fridman WH; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Inflammation, Complement and Cancer Team, Paris, France. Electronic address: herve.fridman@crc.jussieu.fr.
  • Miller I; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Sautès-Fridman C; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Inflammation, Complement and Cancer Team, Paris, France.
  • Byrne AT; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Gastroenterology ; 158(2): 303-321, 2020 01.
Article in En | MEDLINE | ID: mdl-31622621
Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of the tumor microenvironment serve as therapeutic targets and might be used as prognostic factors. For example, immune checkpoint inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents may be used in combination with other drugs to slow or inhibit tumor growth. We review the features of the colorectal tumor stroma that are associated with patient outcomes and discuss potential therapeutic agents that target these features.
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Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Angiogenesis Inhibitors / Tumor Microenvironment / Antineoplastic Agents, Immunological Type of study: Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article

Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Angiogenesis Inhibitors / Tumor Microenvironment / Antineoplastic Agents, Immunological Type of study: Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article