Synthetic and biological approaches to map substrate specificities of proteases.

Chen, Shiyu; Yim, Joshua J; Bogyo, Matthew

Chen, Shiyu; Yim, Joshua J; Bogyo, Matthew.

Affiliation

Chen S; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yim JJ; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bogyo M; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Biol Chem ; 401(1): 165-182, 2019 12 18.

Article in En | MEDLINE | ID: mdl-31639098

Subject(s)

Peptide Hydrolases/genetics; Peptides/genetics; Substrate Specificity/genetics; Humans; Peptide Hydrolases/chemistry; Peptides/antagonists & inhibitors; Peptides/chemistry; Protease Inhibitors/chemistry; Signal Transduction/genetics

Key words

activity-based probe; combinatorial peptide library; protease reactive warhead; protease substrate; proteomics; substrate specificity

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Full text: 1 Database: MEDLINE Main subject: Peptide Hydrolases / Peptides / Substrate Specificity Limits: Humans Language: En Year: 2019 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Peptide Hydrolases / Peptides / Substrate Specificity Limits: Humans Language: En Year: 2019 Type: Article