Protective effects of olmesartan and l-carnitine on doxorubicin-induced cardiotoxicity in rats.

Aziz, Malek M; Abd El Fattah, Mai A; Ahmed, Kawkab A; Sayed, Helmy M

Aziz, Malek M; Abd El Fattah, Mai A; Ahmed, Kawkab A; Sayed, Helmy M.

Affiliation

Aziz MM; Faculty of Medicine and Health Science, Thamar University, Yemen.
Abd El Fattah MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr Al-Aini St., Cairo 11562, Egypt.
Ahmed KA; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Egypt.
Sayed HM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr Al-Aini St., Cairo 11562, Egypt.

Can J Physiol Pharmacol ; 98(4): 183-193, 2020 Apr.

Article in En | MEDLINE | ID: mdl-31665614

Subject(s)

Cardiotoxicity/drug therapy; Carnitine/pharmacology; Doxorubicin/pharmacology; Imidazoles/pharmacology; Protective Agents/pharmacology; Tetrazoles/pharmacology; Animals; Antioxidants/pharmacology; Apoptosis/drug effects; Cardiotoxicity/etiology; Cardiotoxicity/metabolism; Creatine Kinase, MB Form/metabolism; Heart/drug effects; Inflammation/drug therapy; Inflammation/metabolism; L-Lactate Dehydrogenase/metabolism; Male; Malondialdehyde/metabolism; Myocardium/metabolism; Oxidative Stress/drug effects; Rats; Troponin I/metabolism; Tumor Necrosis Factor-alpha/metabolism

Key words

cardiotoxicity; cardiotoxicité; doxorubicin; doxorubicine; echocardiograph; l-carnitine; olmesartan; olmésartan; échocardiographie

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Full text: 1 Database: MEDLINE Main subject: Tetrazoles / Carnitine / Doxorubicin / Protective Agents / Cardiotoxicity / Imidazoles Type of study: Etiology_studies Limits: Animals Language: En Year: 2020 Type: Article

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