Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation.
J Inorg Biochem
; 203: 110908, 2020 02.
Article
in En
| MEDLINE
| ID: mdl-31683125
ABSTRACT
Two new dimeric Zn(II) ([{ZnL1(DMSO2)}2]·DMSO (1), [{ZnL2Cl}2] (2)) and a novel tetrameric Zn(II) complex ([(Zn2L3)2(µ-OAc)2(µ3-O)2] (3)), where H2L1â¯=â¯4-(p-methoxyphenyl) thiosemicarbazone of o-hydroxynapthaldehyde, HL2â¯=â¯4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H2L3â¯=â¯4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal X-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (1012â¯M-1), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, circular dichroism and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 103 to 104â¯M-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Organometallic Compounds
/
Thiosemicarbazones
/
Zinc
/
Coordination Complexes
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Year:
2020
Type:
Article