High information content assays for genetic toxicology testing: A report of the International Workshops on Genotoxicity Testing (IWGT).

Dertinger, Stephen D; Totsuka, Yukari; Bielas, Jason H; Doherty, Ann T; Kleinjans, Jos; Honma, Masamitsu; Marchetti, Francesco; Schuler, Maik J; Thybaud, Veronique; White, Paul; Yauk, Carole L

Dertinger, Stephen D; Totsuka, Yukari; Bielas, Jason H; Doherty, Ann T; Kleinjans, Jos; Honma, Masamitsu; Marchetti, Francesco; Schuler, Maik J; Thybaud, Veronique; White, Paul; Yauk, Carole L.

Affiliation

Dertinger SD; Litron Laboratories, Rochester, NY, USA. Electronic address: sdertinger@litronlabs.com.
Totsuka Y; Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, Tokyo, Japan.
Bielas JH; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Doherty AT; Mechanistic Safety and ADME Sciences, DSM, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Kleinjans J; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.
Honma M; Division of Genetics & Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan.
Marchetti F; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Schuler MJ; Pfizer Global Research and Development, Groton, CT, USA.
Thybaud V; Sanofi, Vitry-sur-Seine, France.
White P; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Yauk CL; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada. Electronic address: carole.yauk@canada.ca.

Mutat Res Genet Toxicol Environ Mutagen ; 847: 403022, 2019 Nov.

Article in En | MEDLINE | ID: mdl-31699343

Subject(s)

Mutagenicity Tests/methods; Animals; Big Data; Cell Line; DNA Adducts/analysis; DNA Barcoding, Taxonomic/methods; DNA Damage; Data Mining; Drug Evaluation, Preclinical; Gene Expression Profiling/methods; High-Throughput Nucleotide Sequencing; Humans; Image Processing, Computer-Assisted; Mass Spectrometry/methods; Meta-Analysis as Topic; Mice; Mutagenicity Tests/standards; Phenotype; Single Molecule Imaging; Toxicology/methods; Transcriptome

Key words

Adductomics; Error-reduced sequencing; Genetic toxicology; High information content; New technologies; Transcriptomics

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Full text: 1 Database: MEDLINE Main subject: Mutagenicity Tests Type of study: Prognostic_studies / Systematic_reviews Limits: Animals / Humans Language: En Year: 2019 Type: Article

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