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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates.
Tomassetti, Mara; Lupidi, Gabriele; Piermattei, Pamela; Rossi, Federico V; Lillini, Samuele; Bianchini, Gianluca; Aramini, Andrea; Ciufolini, Marco A; Marcantoni, Enrico.
Affiliation
  • Tomassetti M; Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.
  • Lupidi G; School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
  • Piermattei P; School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
  • Rossi FV; School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
  • Lillini S; Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.
  • Bianchini G; Dompé Farmaceutici S.p.A., Via Campo di Pile, L'Aquila 67100, Italy.
  • Aramini A; Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.
  • Ciufolini MA; Dompé Farmaceutici S.p.A., Via Campo di Pile, L'Aquila 67100, Italy.
  • Marcantoni E; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Molecules ; 24(21)2019 Oct 25.
Article in En | MEDLINE | ID: mdl-31731437
ABSTRACT
A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
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Full text: 1 Database: MEDLINE Main subject: Thiazoles / Molecular Structure / Cyclization Language: En Year: 2019 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Thiazoles / Molecular Structure / Cyclization Language: En Year: 2019 Type: Article