Control of Regulatory T Cells by Co-signal Molecules.
Adv Exp Med Biol
; 1189: 179-210, 2019.
Article
in En
| MEDLINE
| ID: mdl-31758535
ABSTRACT
Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of Treg suppressive function is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. However, Tregs themselves also depend on many of the same co-signals for their own homeostasis, making this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling in Treg cell biology.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Signal Transduction
/
T-Lymphocytes, Regulatory
Limits:
Humans
Language:
En
Year:
2019
Type:
Article