The steroid receptor coactivator 1 (SRC1) and 3 (SRC3) recruitment as a novel molecular initiating event of 4-n-nonylphenol in estrogen receptor &#945;-mediated pathways.

Ji, Xiaoya; Li, Na; Yang, Rong; Rao, Kaifeng; Ma, Mei; Wang, Zijian

The steroid receptor coactivator 1 (SRC1) and 3 (SRC3) recruitment as a novel molecular initiating event of 4-n-nonylphenol in estrogen receptor α-mediated pathways.

Ji, Xiaoya; Li, Na; Yang, Rong; Rao, Kaifeng; Ma, Mei; Wang, Zijian.

Affiliation

Ji X; Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
Li N; Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
Yang R; Beijing Water Quality Monitoring Center for South-to-North Water Diversion, Beijing, 100093, China.
Rao K; Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
Ma M; Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: mamei@rcees.ac.cn
Wang Z; Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

Ecotoxicol Environ Saf ; 189: 109958, 2020 Feb.

Article in En | MEDLINE | ID: mdl-31767456

Subject(s)

Environmental Pollutants/pharmacology; Estrogen Receptor alpha/metabolism; Estrogens/pharmacology; Nuclear Receptor Coactivator 1/metabolism; Nuclear Receptor Coactivator 3/metabolism; Phenols/pharmacology; Cell Proliferation/drug effects; Humans; MCF-7 Cells

Key words

4-n-Nonylphenol; Estrogen receptor α (ERα); Estrogenic activity; Molecular initiating event (MIE); Steroid receptor coactivator (SRC)

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Full text: 1 Database: MEDLINE Main subject: Phenols / Estrogen Receptor alpha / Environmental Pollutants / Estrogens / Nuclear Receptor Coactivator 1 / Nuclear Receptor Coactivator 3 Limits: Humans Language: En Year: 2020 Type: Article

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