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Increased inflammasome activity in markedly ill psychiatric patients: An explorative study.
Hylén, Ulrika; Eklund, Daniel; Humble, Mats; Bartoszek, Jakub; Särndahl, Eva; Bejerot, Susanne.
Affiliation
  • Hylén U; University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden. Ele
  • Eklund D; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden. Electronic address: daniel.eklund@oru.se.
  • Humble M; University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden. Ele
  • Bartoszek J; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
  • Särndahl E; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden. Electronic address: eva.sarndahl@oru.se.
  • Bejerot S; University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden. Ele
J Neuroimmunol ; 339: 577119, 2020 02 15.
Article in En | MEDLINE | ID: mdl-31786499
ABSTRACT
The aim of this study was to investigate inflammatory perturbations in 40 patients with severe and complex psychiatric disorders by studying the activity of the NLRP3 inflammasome, with a trans-diagnostic approach. Gene expression of CASP1, NLRP3, PYCARD, IL1B, IL1RN, TNF showed a significant increase in the patient group compared to a matched control group. Plasma levels of IL1Ra, IL-18, TNF, IL-6 and CRP were increased in the patient group. Within the patient group, increased gene expression of inflammatory markers correlated with increased disease severity. The findings support the inflammation hypothesis for markedly ill psychiatric patients across diagnostic groups.
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Full text: 1 Database: MEDLINE Main subject: Severity of Illness Index / Inflammasomes / Mental Disorders Type of study: Diagnostic_studies / Observational_studies Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Severity of Illness Index / Inflammasomes / Mental Disorders Type of study: Diagnostic_studies / Observational_studies Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article