Increased serum uric acid level predicts poor prognosis in mildly severe chronic heart failure with reduced ejection fraction. An analysis from the MECKI score research group.
Eur J Intern Med
; 72: 47-52, 2020 02.
Article
in En
| MEDLINE
| ID: mdl-31787490
ABSTRACT
BACKGROUND:
Hyperuricemia prognostic impact on clinical outcomes in chronic heart failure (HF) patients has been investigated with inconclusive results.OBJECTIVES:
Aim of the study was to evaluate the prognostic impact of serum uric acid (SUA) on long-term clinical outcomes in HF.METHODS:
An analysis of MECKI (Metabolic Exercise Cardiac Kidney Index) database, with median follow-up of 3.4 years.RESULTS:
Relation between SUA and all-cause/ cardiovascular (CV) deaths have been analysed in 4,577 patients (3,688 males, age 62.7⯱â¯12.9 years), with reduced ejection fraction HF (35 ± 11%), peakVO2 1151 ± 440â¯ml/min; NYHA class I-II (72.6%), III-IV (27.4%). SUA was associated with increased total and CV mortality (HR 1.120 and HR 1.128, respectively p < 0.0001), also after adjustment for peakVO2, VE/VCO2 slope, diuretic use and MECKI score. SUA was significantly associated with CV mortality only in NYHA class I-II (HR 1.17, p < 0.0001) while there was no association in class III-IV (HR 1.03, p = NS). No prognostic added values of SUA with respect to the MECKI score was observed at the ROC analysis.CONCLUSIONS:
SUA is confirmed to be associated with increased mortality, but in less severe HF only. However SUA did not show additional prognostic power to the MECKI score.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Ventricular Dysfunction, Left
/
Heart Failure
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Humans
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Male
/
Middle aged
Language:
En
Year:
2020
Type:
Article