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The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse models.
Lee, Yu-Young; Park, Jin-Sun; Leem, Yea-Hyun; Park, Jung-Eun; Kim, Do-Yeon; Choi, Youn-Hee; Park, Eun-Mi; Kang, Jihee Lee; Kim, Hee-Sun.
Affiliation
  • Lee YY; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Park JS; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Leem YH; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Park JE; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Kim DY; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Choi YH; Department of Physiology and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.
  • Park EM; Department of Pharmacology and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.
  • Kang JL; Department of Brain & Cognitive Sciences, Ewha Womans University, Seoul, South Korea.
  • Kim HS; Department of Physiology and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.
J Neuroinflammation ; 16(1): 246, 2019 Dec 02.
Article in En | MEDLINE | ID: mdl-31791357
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Full text: 1 Database: MEDLINE Main subject: Papaverine / Phosphodiesterase Inhibitors / Cyclic AMP-Dependent Protein Kinases / Neuroprotective Agents / Parkinsonian Disorders / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Papaverine / Phosphodiesterase Inhibitors / Cyclic AMP-Dependent Protein Kinases / Neuroprotective Agents / Parkinsonian Disorders / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Year: 2019 Type: Article