ß-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1.

Thomaidou, Sofia; Kracht, Maria J L; van der Slik, Arno; Laban, Sandra; de Koning, Eelco J; Carlotti, Francoise; Hoeben, Rob C; Roep, Bart O; Zaldumbide, Arnaud

Thomaidou, Sofia; Kracht, Maria J L; van der Slik, Arno; Laban, Sandra; de Koning, Eelco J; Carlotti, Francoise; Hoeben, Rob C; Roep, Bart O; Zaldumbide, Arnaud.

Affiliation

Thomaidou S; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Kracht MJL; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
van der Slik A; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Laban S; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
de Koning EJ; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Carlotti F; Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Hoeben RC; Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Roep BO; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Zaldumbide A; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

Diabetes ; 69(4): 670-680, 2020 04.

Article in En | MEDLINE | ID: mdl-31896552

Subject(s)

Aminopeptidases/metabolism; CD8-Positive T-Lymphocytes/metabolism; Endoplasmic Reticulum Stress/physiology; Endoribonucleases/metabolism; Insulin-Secreting Cells/metabolism; Insulin/metabolism; Minor Histocompatibility Antigens/metabolism; Protein Precursors/metabolism; Protein Serine-Threonine Kinases/metabolism; Aminopeptidases/genetics; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/immunology; Down-Regulation/drug effects; Endoplasmic Reticulum Stress/drug effects; Endoribonucleases/genetics; HEK293 Cells; Humans; Inflammation/genetics; Inflammation/metabolism; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/immunology; Interferon-gamma/pharmacology; Interleukin-1beta/pharmacology; MicroRNAs/genetics; MicroRNAs/metabolism; Minor Histocompatibility Antigens/genetics; Protein Serine-Threonine Kinases/genetics; Up-Regulation

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Protein Precursors / Minor Histocompatibility Antigens / Protein Serine-Threonine Kinases / CD8-Positive T-Lymphocytes / Endoribonucleases / Insulin-Secreting Cells / Endoplasmic Reticulum Stress / Aminopeptidases / Insulin Limits: Humans Language: En Year: 2020 Type: Article

Fulltext

XML

PubMed Links

Search on Google