[Cariprazine for acute and maintenance treatment of schizophrenia]. / Cariprazine voor acute en onderhouds-behandeling van schizofrenie.
Tijdschr Psychiatr
; 61(10): 702-709, 2019.
Article
in Nl
| MEDLINE
| ID: mdl-31907914
ABSTRACT
BACKGROUND:
Since 2018, cariprazine has been available for the treatment of schizophrenia on the Dutch and Belgian markets.AIM:
To give an overview of the indications, effectiveness and side effects of cariprazine. To make an inventory of the advantages and disadvantages of this new antipsychotic drug.METHOD:
A clinically oriented literature review of published clinical studies and pharmacodynamic and -kinetic publications.RESULTS:
Cariprazine is unique because of its preferential D3 receptor partial agonist affinity and has, in theory, a beneficial effect on negative symptoms. The antipsychotic has two active metabolites desmethylcariprazine and didesmethylcariprazine. The long half-life of cariprazine indicates that, in theory, the drug should not be given daily. Cariprazine is metabolized by cyp3a4 and to a lesser extent by cyp2d6 enzymes. Extrapyramidal symptoms and akathisia are relatively frequent side effects. In contrast, metabolic side effects and weight gain have been reported rarely.CONCLUSION:
Cariprazine can be an effective treatment option for schizophrenia. The final positioning of this antipsychotic drug will have to be based on future research.
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Database:
MEDLINE
Main subject:
Piperazines
/
Schizophrenia
/
Antipsychotic Agents
Limits:
Humans
Language:
Nl
Year:
2019
Type:
Article