Comparative structure, dynamics and evolution of acyl-carrier proteins from Borrelia burgdorferi, Brucella melitensis and Rickettsia prowazekii.

Barnwal, Ravi P; Kaur, Mandeep; Heckert, Alec; Gartia, Janeka; Varani, Gabriele

Barnwal, Ravi P; Kaur, Mandeep; Heckert, Alec; Gartia, Janeka; Varani, Gabriele.

Affiliation

Barnwal RP; Department of Biophysics, Panjab University, Chandigarh 160014, India.
Kaur M; Department of Chemistry, University of Washington, Seattle 98195, WA, U.S.A.
Heckert A; Department of Biophysics, Panjab University, Chandigarh 160014, India.
Gartia J; Department of Chemistry, University of Washington, Seattle 98195, WA, U.S.A.
Varani G; Center for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Gopanpally, Hyderabad 500075, India.

Biochem J ; 477(2): 491-508, 2020 01 31.

Article in En | MEDLINE | ID: mdl-31922183

Subject(s)

Acyl Carrier Protein/ultrastructure; Bacterial Infections/microbiology; Fatty Acid Synthases/ultrastructure; Protein Conformation; Acyl Carrier Protein/chemistry; Acyl Carrier Protein/genetics; Amino Acid Sequence/genetics; Bacterial Infections/drug therapy; Borrelia burgdorferi/chemistry; Borrelia burgdorferi/pathogenicity; Borrelia burgdorferi/ultrastructure; Brucella melitensis/chemistry; Brucella melitensis/pathogenicity; Brucella melitensis/ultrastructure; Catalytic Domain; Fatty Acid Synthases/chemistry; Fatty Acid Synthases/genetics; Host-Pathogen Interactions/genetics; Humans; Lipid A/chemistry; Lipid A/genetics; Molecular Dynamics Simulation; Multienzyme Complexes; Nuclear Magnetic Resonance, Biomolecular; Protein Binding/genetics; Quorum Sensing/genetics; Rickettsia prowazekii/chemistry; Rickettsia prowazekii/pathogenicity; Rickettsia prowazekii/ultrastructure

Key words

Borrelia burgdorferi; NMR; acyl carrier protein; fatty acid biosynthesis; protein dynamics; protein structure

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Full text: 1 Database: MEDLINE Main subject: Protein Conformation / Bacterial Infections / Acyl Carrier Protein / Fatty Acid Synthases Limits: Humans Language: En Year: 2020 Type: Article

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