Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer.
J Exp Med
; 217(4)2020 04 06.
Article
in En
| MEDLINE
| ID: mdl-31951251
ABSTRACT
Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs) play important roles in cancer progression. Here, we have characterized the ontogeny and function of TAM subsets in a mouse model of metastatic ovarian cancer that is representative for visceral peritoneal metastasis. We show that the omentum is a critical premetastatic niche for development of invasive disease in this model and define a unique subset of CD163+ Tim4+ resident omental macrophages responsible for metastatic spread of ovarian cancer cells. Transcriptomic analysis showed that resident CD163+ Tim4+ omental macrophages were phenotypically distinct and maintained their resident identity during tumor growth. Selective depletion of CD163+ Tim4+ macrophages in omentum using genetic and pharmacological tools prevented tumor progression and metastatic spread of disease. These studies describe a specific role for tissue-resident macrophages in the invasive progression of metastatic ovarian cancer. The molecular pathways of cross-talk between tissue-resident macrophages and disseminated cancer cells may represent new targets to prevent metastasis and disease recurrence.
Full text:
1
Database:
MEDLINE
Main subject:
Omentum
/
Ovarian Neoplasms
/
Peritoneal Neoplasms
/
Macrophages
Limits:
Animals
Language:
En
Year:
2020
Type:
Article