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Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays.
Ren, Albert; Zhu, Xiuwen; Feichtinger, Konrad; Lehman, Juerg; Kasem, Michelle; Schrader, Thomas O; Wong, Amy; Dang, Huong; Le, Minh; Frazer, John; Unett, David J; Grottick, Andrew J; Whelan, Kevin T; Morgan, Michael E; Sage, Carleton R; Semple, Graeme.
Affiliation
  • Ren A; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Zhu X; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Feichtinger K; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Lehman J; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Kasem M; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Schrader TO; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Wong A; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Dang H; Beacon Discovery, 6118 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Le M; Beacon Discovery, 6118 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Frazer J; Beacon Discovery, 6118 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Unett DJ; Beacon Discovery, 6118 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Grottick AJ; Beacon Discovery, 6118 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Whelan KT; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Morgan ME; Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Sage CR; Beacon Discovery, 6118 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Semple G; Beacon Discovery, 6118 Nancy Ridge Drive, San Diego, CA 92121, USA. Electronic address: gsemple@beacondiscovery.com.
Bioorg Med Chem Lett ; 30(5): 126929, 2020 03 01.
Article in En | MEDLINE | ID: mdl-31952960
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Full text: 1 Database: MEDLINE Main subject: Benzodiazepines / Receptor, Serotonin, 5-HT2C / Serotonin 5-HT2 Receptor Agonists / Heterocyclic Compounds, 3-Ring Limits: Animals / Humans / Male Language: En Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Benzodiazepines / Receptor, Serotonin, 5-HT2C / Serotonin 5-HT2 Receptor Agonists / Heterocyclic Compounds, 3-Ring Limits: Animals / Humans / Male Language: En Year: 2020 Type: Article