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Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation.
Awada, Hassan; Mahfouz, Reda Z; Durrani, Jibran; Kishtagari, Ashwin; Jagadeesh, Deepa; Lichtin, Alan E; Hill, Brian T; Hamilton, Betty K; Carraway, Hetty E; Nazha, Aziz; Majhail, Navneet S; Sobecks, Ronald; Visconte, Valeria; Kalaycio, Matt; Sekeres, Mikkael A; Maciejewski, Jaroslaw P.
Affiliation
  • Awada H; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Mahfouz RZ; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Durrani J; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Kishtagari A; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Jagadeesh D; Lymphoid Malignancies Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Lichtin AE; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Hill BT; Lymphoid Malignancies Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Hamilton BK; Blood and Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Carraway HE; Leukaemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Nazha A; Leukaemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Majhail NS; Blood and Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Sobecks R; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Visconte V; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Kalaycio M; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Sekeres MA; Leukaemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Maciejewski JP; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Br J Haematol ; 189(2): 318-322, 2020 04.
Article in En | MEDLINE | ID: mdl-31958160
T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, we studied the clinical characterization of these cases and compared them to de novo T-LGLL. This experience represented a clear picture of the intricate nature of the disease manifestation and the complexities of several immune mechanisms triggering the clonal expansion.
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Full text: 1 Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / Transplantation Conditioning / Leukemia, Large Granular Lymphocytic Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / Transplantation Conditioning / Leukemia, Large Granular Lymphocytic Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article