Glioblastomas exploit truncated O<i>-</i>linked glycans for local and distant immune modulation via the macrophage galactose-type lectin.

Dusoswa, Sophie A; Verhoeff, Jan; Abels, Erik; Méndez-Huergo, Santiago P; Croci, Diego O; Kuijper, Lisan H; de Miguel, Elena; Wouters, Valerie M C J; Best, Myron G; Rodriguez, Ernesto; Cornelissen, Lenneke A M; van Vliet, Sandra J; Wesseling, Pieter; Breakefield, Xandra O; Noske, David P; Würdinger, Thomas; Broekman, Marike L D; Rabinovich, Gabriel A; van Kooyk, Yvette; Garcia-Vallejo, Juan J

Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin.

Dusoswa, Sophie A; Verhoeff, Jan; Abels, Erik; Méndez-Huergo, Santiago P; Croci, Diego O; Kuijper, Lisan H; de Miguel, Elena; Wouters, Valerie M C J; Best, Myron G; Rodriguez, Ernesto; Cornelissen, Lenneke A M; van Vliet, Sandra J; Wesseling, Pieter; Breakefield, Xandra O; Noske, David P; Würdinger, Thomas; Broekman, Marike L D; Rabinovich, Gabriel A; van Kooyk, Yvette; Garcia-Vallejo, Juan J.

Affiliation

Dusoswa SA; Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Verhoeff J; Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Abels E; Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Méndez-Huergo SP; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02129.
Croci DO; Department of Radiology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02129.
Kuijper LH; Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1428ADN Buenos Aires, Argentina.
de Miguel E; Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1428ADN Buenos Aires, Argentina.
Wouters VMCJ; Laboratorio de Inmunopatología, Instituto de Histología y Embriología de Mendoza, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina.
Best MG; Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Rodriguez E; Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Cornelissen LAM; Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
van Vliet SJ; Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Wesseling P; Department of Pathology, Cancer Center Amsterdam and Brain Tumor Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Breakefield XO; Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Noske DP; Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Würdinger T; Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Broekman MLD; Department of Pathology, Cancer Center Amsterdam and Brain Tumor Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Rabinovich GA; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02129.
van Kooyk Y; Department of Radiology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02129.
Garcia-Vallejo JJ; Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.

Proc Natl Acad Sci U S A ; 117(7): 3693-3703, 2020 02 18.

Article in En | MEDLINE | ID: mdl-32019882

Subject(s)

Asialoglycoproteins/immunology; Glioblastoma/immunology; Lectins, C-Type/immunology; Membrane Proteins/immunology; Animals; Antigens, CD/genetics; Antigens, CD/immunology; Antigens, Differentiation, Myelomonocytic/genetics; Antigens, Differentiation, Myelomonocytic/immunology; Asialoglycoproteins/chemistry; Asialoglycoproteins/genetics; Glioblastoma/genetics; Humans; Lectins, C-Type/chemistry; Lectins, C-Type/genetics; Macrophages/immunology; Male; Membrane Proteins/chemistry; Membrane Proteins/genetics; Mice; Mice, Inbred C57BL; Microglia/immunology; Polysaccharides/chemistry; Polysaccharides/immunology; Receptors, Cell Surface/genetics; Receptors, Cell Surface/immunology

Key words

O-linked glycosylation; glioblastoma; immunosuppression; macrophage galactose lectin; macrophages

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Full text: 1 Database: MEDLINE Main subject: Asialoglycoproteins / Glioblastoma / Lectins, C-Type / Membrane Proteins Limits: Animals / Humans / Male Language: En Year: 2020 Type: Article

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