Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-&#954;B activity.

Chen, Junwen; Tong, Wei; Liao, Mingxin; Chen, Dengyi

Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-κB activity.

Chen, Junwen; Tong, Wei; Liao, Mingxin; Chen, Dengyi.

Affiliation

Chen J; Department of Respiratory and Critical Care Medicine, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Tong W; Department of Clinical Laboratory, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China. Electronic address: tongwei130523@sina.com.
Liao M; Department of Clinical Laboratory, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Chen D; Department of Clinical Laboratory, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.

Biochem Biophys Res Commun ; 524(4): 803-809, 2020 04 16.

Article in En | MEDLINE | ID: mdl-32037090

Subject(s)

Arachidonate 12-Lipoxygenase/genetics; Epithelial-Mesenchymal Transition/genetics; Gene Expression Regulation, Neoplastic; Lung Neoplasms/genetics; NF-kappa B/genetics; Small Cell Lung Carcinoma/genetics; rhoA GTP-Binding Protein/genetics; Apoptosis/genetics; Arachidonate 12-Lipoxygenase/metabolism; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial Cells/metabolism; Epithelial Cells/pathology; Flavanones/pharmacology; Humans; Immunohistochemistry; Lipoxygenase Inhibitors/pharmacology; Lung Neoplasms/metabolism; Lung Neoplasms/pathology; NF-kappa B/metabolism; Organ Specificity; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Signal Transduction; Small Cell Lung Carcinoma/metabolism; Small Cell Lung Carcinoma/pathology; rhoA GTP-Binding Protein/metabolism

Key words

12-HETE; Alox12; EMT; Lung cancer; NF-κB; RhoA

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Full text: 1 Database: MEDLINE Main subject: Arachidonate 12-Lipoxygenase / Gene Expression Regulation, Neoplastic / NF-kappa B / RhoA GTP-Binding Protein / Small Cell Lung Carcinoma / Epithelial-Mesenchymal Transition / Lung Neoplasms Limits: Humans Language: En Year: 2020 Type: Article

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