Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling.

Blume, Zachary I; Lambert, Jared M; Lovel, Anna G; Mitchell, Diana M

Blume, Zachary I; Lambert, Jared M; Lovel, Anna G; Mitchell, Diana M.

Affiliation

Blume ZI; Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Lambert JM; Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Lovel AG; Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Mitchell DM; Biological Sciences, University of Idaho, Moscow, Idaho, USA.

Dev Dyn ; 249(6): 723-740, 2020 06.

Article in En | MEDLINE | ID: mdl-32072708

Subject(s)

Microglia/cytology; Microglia/metabolism; Receptors, Purinergic P2Y12/metabolism; Retina/cytology; Retina/metabolism; Animals; Apoptosis/drug effects; Apoptosis/physiology; Metronidazole/pharmacology; Microglia/drug effects; Phagocytosis/drug effects; Phagocytosis/physiology; Receptors, Purinergic P2Y12/genetics; Retina/drug effects; Signal Transduction/drug effects

Key words

developmental apoptosis; microglia; p2ry12; phagocytosis; retina; zebrafish

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Full text: 1 Database: MEDLINE Main subject: Retina / Microglia / Receptors, Purinergic P2Y12 Limits: Animals Language: En Year: 2020 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Retina / Microglia / Receptors, Purinergic P2Y12 Limits: Animals Language: En Year: 2020 Type: Article