Chemical Biology Framework to Illuminate Proteostasis.

Sebastian, Rebecca M; Shoulders, Matthew D

Sebastian, Rebecca M; Shoulders, Matthew D.

Affiliation

Sebastian RM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: mshoulde@mit.edu.
Shoulders MD; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: mshoulde@mit.edu.

Annu Rev Biochem ; 89: 529-555, 2020 06 20.

Article in En | MEDLINE | ID: mdl-32097570

Subject(s)

Molecular Chaperones/genetics; Molecular Probe Techniques; Proteome/genetics; Proteostasis Deficiencies/genetics; Proteostasis/genetics; Animals; CRISPR-Cas Systems; Gene Expression Regulation; Half-Life; Heat-Shock Response/drug effects; Humans; Molecular Chaperones/metabolism; Protein Aggregates; Protein Engineering/methods; Protein Folding/drug effects; Protein Transport/drug effects; Proteome/chemistry; Proteome/metabolism; Proteostasis/drug effects; Proteostasis Deficiencies/metabolism; Proteostasis Deficiencies/pathology; Signal Transduction; Small Molecule Libraries/chemical synthesis; Small Molecule Libraries/pharmacology; Unfolded Protein Response/drug effects

Key words

aggregation; cellular protein folding; heat shock response; protein-misfolding stress response; quality control; unfolded protein response

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Molecular Probe Techniques / Molecular Chaperones / Proteome / Proteostasis Deficiencies / Proteostasis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2020 Type: Article

Fulltext

XML

PubMed Links

Search on Google