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Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine.
Liu, Xui-Fen; Wei, Junxia; Zhou, Qi; Molitoris, Bruce A; Sandoval, Ruben; Kobayashi, Hisataka; Okada, Ryuhei; Nagaya, Tadanobu; Karim, Baktiar; Butcher, Donna; Pastan, Ira.
Affiliation
  • Liu XF; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
  • Wei J; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
  • Zhou Q; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
  • Molitoris BA; Department of Medicine, Division of Nephrology, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202.
  • Sandoval R; Nephrology Research II, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202.
  • Kobayashi H; Department of Medicine, Division of Nephrology, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202.
  • Okada R; Nephrology Research II, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202.
  • Nagaya T; Molecular Imaging Program, National Cancer Institute, Bethesda, MD 20892.
  • Karim B; Molecular Imaging Program, National Cancer Institute, Bethesda, MD 20892.
  • Butcher D; Molecular Imaging Program, National Cancer Institute, Bethesda, MD 20892.
  • Pastan I; Pathology/Histotechnology Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Proc Natl Acad Sci U S A ; 117(11): 6086-6091, 2020 03 17.
Article in En | MEDLINE | ID: mdl-32123080
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Full text: 1 Database: MEDLINE Main subject: Immunotoxins / Capillary Leak Syndrome / Albuminuria / Kidney Tubules, Proximal / Antibodies, Monoclonal Type of study: Prognostic_studies Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Immunotoxins / Capillary Leak Syndrome / Albuminuria / Kidney Tubules, Proximal / Antibodies, Monoclonal Type of study: Prognostic_studies Language: En Year: 2020 Type: Article