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In vitro-in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization.
Morita, Keiichi; Kato, Motohiro; Kudo, Toshiyuki; Ito, Kiyomi.
Affiliation
  • Morita K; Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.
  • Kato M; Translational Research Division, Chugai Pharmaceutical, Co., Ltd, Kanagawa, Japan.
  • Kudo T; Research Division, Chugai Pharmaceutical, Co., Ltd, Shizuoka, Japan.
  • Ito K; Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.
Xenobiotica ; 50(9): 1064-1075, 2020 Sep.
Article in En | MEDLINE | ID: mdl-32125203
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Full text: 1 Database: MEDLINE Main subject: Microsomes, Liver / Metabolic Clearance Rate Type of study: Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Microsomes, Liver / Metabolic Clearance Rate Type of study: Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article