ADME, Absorption, distribution, metabolism, and excretion; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUC, area under the curve; Bw, body weight; C, Catechin; CAM, causality assessment method; CG, (+)­catechin­3­gallate; CIH, Concanavalin A-induced hepatitis; CMC, chemistry, manufacturing, and controls; COMT, catechol­O­methyltransferase; Camellia sinensis; ConA, Concanavalin A; DILI, drug­induced liver injury; DILIN, Drug­Induced Liver Injury Network; DO, Diversity Outbred; DS, Dietary Supplement; DSAE, JS3 USP Dietary Supplements Admission Evaluations Joint Standard-Setting Subcommittee; Dietary supplements; EC, (­)­epicatechin; ECG, (­)­epicatechin­3­gallate; EFSA, European Food Safety Authority; EGC, (­)­epigallocatechin; EGCG, (­)­epigallocatechin­3­gallate; FDA, United States Food and Drug Administration; GC, (+)­gallocatechin; GCG, (­)­gallocatechin­3­gallate; GT(E), green tea or green tea extract; GT, green tea; GTE, green tea extract; GTEH, EP Green Tea Extract Hepatotoxicity Expert Panel; Green tea; Green tea extract; HDS, herbal dietary supplement; HPMC, Hydroxypropyl methylcellulose; Hepatotoxicity; LD50, lethal dose, median; LFT(s), liver function test(s); LT(s), Liver test(s); Liver injury; MGTT, Minnesota Green Tea Trial; MIDS, multi-ingredient dietary supplement; MRL, maximum residue limit; NAA, N-acetyl aspartate; NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases; NIH, National Institutes of Health; NOAEL, no observed adverse effect level; NTP, National Toxicology Program; OSM, online supplementary material; PAs, Pyrrolizidine Alkaloids; PD-1, Programmed death domain-1; PDGTE, powdered decaffeinated green tea extract; PK/PD, pharmacokinetics and pharmacodynamics; RUCAM, Roussel Uclaf Causality Assessment Method; SIDS, single-ingredient dietary supplement; TGF-beta, Transforming growth factor beta; USP, United States Pharmacopeia; γ-GT, Gamma-glutamyl transferase