Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation.

Butts, Brittany; Ahmed, Mustafa I; Bajaj, Navkaranbir S; Cox Powell, Pamela; Pat, Betty; Litovsky, Silvio; Gupta, Himanshu; Lloyd, Steven G; Denney, Thomas S; Zhang, Xiaoxia; Aban, Inmaculada; Sadayappan, Sakthivel; McNamara, James W; Watson, Michael J; Ferrario, Carlos M; Collawn, James F; Lewis, Clifton; Davies, James E; Dell'Italia, Louis J

Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation.

Butts, Brittany; Ahmed, Mustafa I; Bajaj, Navkaranbir S; Cox Powell, Pamela; Pat, Betty; Litovsky, Silvio; Gupta, Himanshu; Lloyd, Steven G; Denney, Thomas S; Zhang, Xiaoxia; Aban, Inmaculada; Sadayappan, Sakthivel; McNamara, James W; Watson, Michael J; Ferrario, Carlos M; Collawn, James F; Lewis, Clifton; Davies, James E; Dell'Italia, Louis J.

Affiliation

Butts B; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Ahmed MI; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Bajaj NS; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Cox Powell P; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Pat B; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Litovsky S; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Gupta H; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Lloyd SG; Department of Veterans Affairs Medical Center, Birmingham, Alabama.
Denney TS; Department of Cardiology, Valley Health System, Paramus, New Jersey.
Zhang X; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Aban I; Department of Veterans Affairs Medical Center, Birmingham, Alabama.
Sadayappan S; Department of Electrical and Computer Engineering, Auburn University School of Engineering, Auburn, Alabama.
McNamara JW; Department of Electrical and Computer Engineering, Auburn University School of Engineering, Auburn, Alabama.
Watson MJ; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama.
Ferrario CM; Division of Cardiovascular Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Collawn JF; Division of Cardiovascular Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Lewis C; Division of Cardiothoracic Surgery, Department of Surgery, Duke University, Durham, North Carolina.
Davies JE; Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, North Carolina.
Dell'Italia LJ; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.

JACC Basic Transl Sci ; 5(2): 109-122, 2020 Feb.

Article in En | MEDLINE | ID: mdl-32140620

Key words

EF, ejection fraction; LA EF, left atrial emptying fraction; LA, left atrial; LV, left ventricle; MR, mitral regurgitation; MV, mitral valve; RA, right atrial; TEM, transmission electron microscopy; TGF, transforming growth factor; chymase; fibrosis; left atrium; left ventricle; mitral regurgitation; mitral valve

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