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A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.
Nemet, Ina; Saha, Prasenjit Prasad; Gupta, Nilaksh; Zhu, Weifei; Romano, Kymberleigh A; Skye, Sarah M; Cajka, Tomas; Mohan, Maradumane L; Li, Lin; Wu, Yuping; Funabashi, Masanori; Ramer-Tait, Amanda E; Naga Prasad, Sathyamangla Venkata; Fiehn, Oliver; Rey, Federico E; Tang, W H Wilson; Fischbach, Michael A; DiDonato, Joseph A; Hazen, Stanley L.
Affiliation
  • Nemet I; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Saha PP; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Gupta N; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Zhu W; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Romano KA; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Skye SM; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Cajka T; West Coast Metabolomics Center, University of California, Davis, Davis, CA 95616, USA.
  • Mohan ML; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Li L; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Wu Y; Department of Mathematics, Cleveland State University, Cleveland, OH 44115, USA.
  • Funabashi M; Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.
  • Ramer-Tait AE; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
  • Naga Prasad SV; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Fiehn O; West Coast Metabolomics Center, University of California, Davis, Davis, CA 95616, USA.
  • Rey FE; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Tang WHW; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA; Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Fischbach MA; Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.
  • DiDonato JA; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.
  • Hazen SL; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA; Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44106, USA. Electronic add
Cell ; 180(5): 862-877.e22, 2020 03 05.
Article in En | MEDLINE | ID: mdl-32142679
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Full text: 1 Database: MEDLINE Main subject: Thrombosis / Cardiovascular Diseases / Gastrointestinal Microbiome / Glutamine Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: En Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Thrombosis / Cardiovascular Diseases / Gastrointestinal Microbiome / Glutamine Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: En Year: 2020 Type: Article