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Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission.
Magalhães, Herbert S; da Silva, Alison B; Nascimento, Nilberto R F; de Sousa, Luis Gustavo F; da Fonseca, Maria Júlia S; Loiola, Maria Iracema B; Monteiro, Norberto K V; Almeida Neto, Francisco Wagner Q; Canuto, Kirley M; Pessoa, Otilia Deusdênia L.
Affiliation
  • Magalhães HS; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60971-270 Fortaleza, CE, Brazil.
  • da Silva AB; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60971-270 Fortaleza, CE, Brazil.
  • Nascimento NRF; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, 60714-903 Fortaleza, CE, Brazil.
  • de Sousa LGF; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, 60714-903 Fortaleza, CE, Brazil.
  • da Fonseca MJS; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, 60714-903 Fortaleza, CE, Brazil.
  • Loiola MIB; Herbário Prisco Bezerra (EAC), Universidade Federal do Ceará, 60440-900 Fortaleza, CE, Brazil.
  • Monteiro NKV; Departmento de Química Analítica e Físico-Química, Universidade Federal do Ceará, 60020-181 Fortaleza, CE, Brazil.
  • Almeida Neto FWQ; Departmento de Química Analítica e Físico-Química, Universidade Federal do Ceará, 60020-181 Fortaleza, CE, Brazil.
  • Canuto KM; Embrapa Agroindústria Tropical, 60511-110 Fortaleza, CE, Brazil.
  • Pessoa ODL; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60971-270 Fortaleza, CE, Brazil. Electronic address: opessoa@ufc.br.
Fitoterapia ; 143: 104545, 2020 Jun.
Article in En | MEDLINE | ID: mdl-32151641
ABSTRACT
The new glucosyl sarpagan alkaloid designated as 21(R*)-(O-ß-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alkaloids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1, 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activity.
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Full text: 1 Database: MEDLINE Main subject: Rauwolfia / Synaptic Transmission / Plant Roots / Indole Alkaloids Limits: Animals Country/Region as subject: America do sul / Brasil Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Rauwolfia / Synaptic Transmission / Plant Roots / Indole Alkaloids Limits: Animals Country/Region as subject: America do sul / Brasil Language: En Year: 2020 Type: Article