Endogenous parathyroid hormone (PTH) signals through osteoblasts via RANKL during fracture healing to affect osteoclasts.

Sun, Peng; Wang, Ming; Yin, Guo-Yong

Sun, Peng; Wang, Ming; Yin, Guo-Yong.

Affiliation

Sun P; Department of Orthopedics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, 223300, China.
Wang M; Department of Plastic and Burn Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Yin GY; Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China. Electronic address: guoyong_yin@sina.com.

Biochem Biophys Res Commun ; 525(4): 850-856, 2020 05 14.

Article in En | MEDLINE | ID: mdl-32169280

Subject(s)

Fracture Healing/physiology; Osteoblasts/metabolism; Osteoclasts/metabolism; Parathyroid Hormone/metabolism; RANK Ligand/metabolism; Animals; Cell Communication; Cells, Cultured; Femoral Fractures/metabolism; Femoral Fractures/pathology; Mice, Knockout; Parathyroid Hormone/genetics; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; STAT5 Transcription Factor/metabolism

Key words

Fracture healing; Osteoblast; Osteoclast; Parathyroid hormone; RANKL

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Full text: 1 Database: MEDLINE Main subject: Osteoblasts / Osteoclasts / Parathyroid Hormone / Fracture Healing / RANK Ligand Type of study: Prognostic_studies Limits: Animals Language: En Year: 2020 Type: Article

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