Neurocognitive correlates of working memory and emotional processing in postpartum psychosis: an fMRI study.
Psychol Med
; 51(10): 1724-1732, 2021 07.
Article
in En
| MEDLINE
| ID: mdl-32174288
ABSTRACT
BACKGROUND:
Postpartum psychosis (PP) is a severe postpartum disorder. While working memory and emotional processing-related brain function are consistently impaired in psychoses unrelated to the puerperium, no studies have investigated them in PP.METHODS:
Twenty-four women at risk of developing PP (11 developed an episode - PE; 13 remained well - NPE) and 20 healthy postpartum women completed two functional magnetic resonance imaging tasks within a year of delivery working memory (n-back) and emotional face recognition (fearful faces). We compared women at-risk of PP to controls, as well as NPE, PE, and controls to test for potential effects of a PP episode occurrence.RESULTS:
Women at-risk of PP and PE showed hyperactivation of lateral visual areas, precuneus, and posterior cingulate during the n-back task. The at-risk group as a whole, as well as the PE and NPE groups, showed hyperconnectivity of the right dorsolateral prefrontal cortex (DLPFC) with various parieto-occipito-temporo-cerebellar regions compared to controls during several n-back conditions. Increases in connectivity between the right DLPFC and ipsilateral middle temporal gyrus were observed in the PE group compared to NPE during 2-back. During the fearful faces task, at-risk women as a group showed hyperactivation of fronto-cingulo-subcortical regions, and hypoconnectivity between the left amygdala and ipsilateral occipito-parietal regions compared to controls. No significant performance differences were observed.CONCLUSIONS:
These results present preliminary evidence of a differential nature of functional brain abnormalities in PP compared to the typically observed reduced connectivity with the DLPFC in psychoses unrelated to puerperium, such as bipolar disorder.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Psychotic Disorders
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Brain
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Postpartum Period
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Emotions
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Facial Recognition
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Memory, Short-Term
Type of study:
Diagnostic_studies
Limits:
Adult
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Female
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Humans
Country/Region as subject:
Europa
Language:
En
Year:
2021
Type:
Article