A threshold linear mixed model for identification of treatment-sensitive subsets in a clinical trial based on longitudinal outcomes and a continuous covariate.

Ge, Xinyi; Peng, Yingwei; Tu, Dongsheng

Ge, Xinyi; Peng, Yingwei; Tu, Dongsheng.

Affiliation

Ge X; Department of Mathematics and Statistics, Queen's University, Kingston, Canada.
Peng Y; Department of Mathematics and Statistics, Queen's University, Kingston, Canada.
Tu D; Departments of Public Health Sciences, Queen's University, Kingston, Canada.

Stat Methods Med Res ; 29(10): 2919-2931, 2020 10.

Article in En | MEDLINE | ID: mdl-32193992

Subject(s)

Algorithms; Quality of Life; Computer Simulation; Humans; Likelihood Functions; Linear Models

Key words

Subgroup analysis; longitudinal data; predictive biomarker; smoothing likelihood function

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Full text: 1 Database: MEDLINE Main subject: Quality of Life / Algorithms Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2020 Type: Article

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