Mitigating effect of paxilline against injury produced by Cd<sup>2+</sup> in rat pheochromocytoma PC12 and ascites hepatoma AS-30D cells.

Belyaeva, Elena A; Sokolova, Tatyana V

Mitigating effect of paxilline against injury produced by Cd²⁺ in rat pheochromocytoma PC12 and ascites hepatoma AS-30D cells.

Belyaeva, Elena A; Sokolova, Tatyana V.

Affiliation

Belyaeva EA; I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, Thorez Pr. 44, 194223, St.-Petersburg, Russia. Electronic address: alenab61@mail.ru.
Sokolova TV; I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, Thorez Pr. 44, 194223, St.-Petersburg, Russia.

Ecotoxicol Environ Saf ; 196: 110519, 2020 Jun 15.

Article in En | MEDLINE | ID: mdl-32244116

Subject(s)

Apoptosis/drug effects; Cadmium/toxicity; Environmental Pollutants/toxicity; Indoles/pharmacology; Mitochondria, Liver/drug effects; Potassium Channel Blockers/pharmacology; Animals; Cell Line, Tumor; Cell Membrane Permeability/drug effects; Cell Survival/drug effects; Membrane Potential, Mitochondrial/drug effects; Mitochondria, Liver/metabolism; Necrosis; PC12 Cells; Rats; Reactive Oxygen Species/metabolism

Key words

Cd(2+)-induced mitochondrial dysfunction-mediated cytotoxicity; Large-conductance potassium channel blocker; Mitochondrial electron transport chain; Paxilline; Protection mechanism(s); Rat liver mitochondria and PC12 and AS-30D cells

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Full text: 1 Database: MEDLINE Main subject: Cadmium / Mitochondria, Liver / Apoptosis / Potassium Channel Blockers / Environmental Pollutants / Indoles Limits: Animals Language: En Year: 2020 Type: Article

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