Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
Biochim Biophys Acta Mol Cell Res
; 1867(7): 118713, 2020 07.
Article
in En
| MEDLINE
| ID: mdl-32246948
ABSTRACT
WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62 is frequently associated with several tumour types, potential effects of excess WDR62 on proliferative growth remain undefined. Here, we demonstrate that glia specific overexpression of WDR62 in Drosophila larval brains resulted in increased cell size, over-proliferation and increased brain volume, without overt disruption of tissue organization. We further demonstrate WDR62 promoted over-proliferation and brain overgrowth by activating AURKA and pAKT signalling to increase MYC function in glial cells. Together these data suggest WDR62 normally functions in the glial lineage to activate oncogenic signalling networks, promoting proliferation and brain overgrowth.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Transcription Factors
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Drosophila Proteins
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DNA-Binding Proteins
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Aurora Kinase A
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Nerve Tissue Proteins
Limits:
Animals
Language:
En
Year:
2020
Type:
Article